KEGG ORTHOLOGY: K10456

ORTHOLOGY: K10456

Entry

K10456                      KO

Symbol

KLHL19, KEAP1, INRF2

Name

kelch-like protein 19

Pathway

map04120

Ubiquitin mediated proteolysis

map05012

Parkinson disease

map05200

Pathways in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05225

Hepatocellular carcinoma

map05418

Fluid shear stress and atherosclerosis

Disease

H00048

Hepatocellular carcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
   05208 Chemical carcinogenesis - reactive oxygen species
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul3 complex
    Adoptor and target recognizing subunit (BTB)
     K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19

Genes

HSA:	9817(KEAP1)

PTR:	455706(KEAP1)

PPS:	100978540(KEAP1)

GGO:	129528881(KEAP1)

PON:	100173389(KEAP1)

PPYG:

129020077(KEAP1)

NLE:	100588449(KEAP1)

HMH:	116478449(KEAP1)

SSYN:

129460545(KEAP1)

MCC:	720514(KEAP1)

MCF:	102118980(KEAP1)

MNI:	105475619(KEAP1)

CSAB:

103233900(KEAP1)

CATY:

105601447(KEAP1)

PANU:

101025614(KEAP1)

TGE:	112612092(KEAP1)

MLEU:

105549825(KEAP1)

RRO:	104670474(KEAP1)

RBB:	108517807 108539981(KEAP1)

TFN:	117076190(KEAP1)

PTEH:

111527757(KEAP1)

CANG:

105520867(KEAP1)

CJC:	100409712(KEAP1)

SBQ:	101029728(KEAP1)

CIMI:

108283686(KEAP1)

ANAN:

105705979(KEAP1)

CSYR:

103252292(KEAP1)

MMUR:

105885588(KEAP1)

LCAT:

123634265(KEAP1)

PCOQ:

105807821(KEAP1)

OGA:	100960934(KEAP1)

MMU:	50868(Keap1)

MCAL:

110301406(Keap1)

MPAH:

110327787(Keap1)

RNO:	117519(Keap1)

MCOC:

116073905(Keap1)

ANU:	117713629(Keap1)

ASYL:

127689351(Keap1)

MUN:	110555771(Keap1)

CGE:	100759410(Keap1)

MAUA:

101831870(Keap1)

PROB:

127231272(Keap1)

PLEU:

114695216(Keap1)

MORG:

121451759(Keap1)

MFOT:

126490522

AAMP:

119810210(Keap1)

NGI:	103747559(Keap1)

HGL:	101718777(Keap1)

CPOC:

100713871(Keap1)

CCAN:

109693174(Keap1)

DORD:

105999069(Keap1)

DSP:	122119563(Keap1)

PLOP:

125348735(Keap1)

NCAR:

124968513

MMMA:

107145182(Keap1)

ITI:	101964420(Keap1)

OCU:

100346935

OPI:	101521346(KEAP1)

TUP:	102490837(KEAP1)

GVR:	103581203(KEAP1)

CFA:	476713(KEAP1)

CLUD:

112666502(KEAP1)

VVP:	112908040(KEAP1)

VLG:	121495316(KEAP1)

NPO:	129508832 129521540(KEAP1)

AML:	100467923(KEAP1)

UMR:	103678690(KEAP1)

UAH:	113242989(KEAP1)

UAR:	123777573(KEAP1)

ELK:

111162515

LLV:

125084836

MPUF:

101678742(KEAP1)

MNP:	132010975(KEAP1)

MLK:	131823520(KEAP1)

NVS:	122909732(KEAP1)

ORO:	101378046(KEAP1)

EJU:	114197721(KEAP1)

ZCA:	113915830(KEAP1)

MLX:	118006049(KEAP1)

NSU:	110593664(KEAP1)

LWW:	102751053(KEAP1)

FCA:	101091260(KEAP1)

PYU:	121013978(KEAP1)

PCOO:

112852265(KEAP1)

PBG:	122486862(KEAP1)

PVIV:

125152386(KEAP1)

LRUF:

124523929

LGF:	123605275(KEAP1)

AJU:

106980317

PTG:	102969048(KEAP1)

PPAD:

109254110(KEAP1)

PUC:

125930546

PLEZ:

122213957(KEAP1)

HHV:	120244455(KEAP1)

BTA:	532791(KEAP1)

BOM:	102288117(KEAP1)

BIU:	109561590(KEAP1)

BBUB:

102404883(KEAP1)

BBIS:

104979822(KEAP1)

CHX:	102182688(KEAP1)

OAS:	101113845(KEAP1)

BTAX:

128051696(KEAP1)

CSUM:

138085462(KEAP1)

ODA:	120863970(KEAP1)

CCAD:

122440418(KEAP1)

MREE:

136155731(KEAP1)

OVR:	110142927(KEAP1)

MBEZ:

129558639(KEAP1)

SSC:	100136900(KEAP1)

CFR:	102508840(KEAP1)

CBAI:

105068384(KEAP1)

CDK:	105087634(KEAP1)

VPC:	102529949(KEAP1)

BACU:

103016742(KEAP1)

BMUS:

118892363(KEAP1)

LVE:	103083057(KEAP1)

OOR:	101279074(KEAP1)

LALB:

132517631(KEAP1)

DLE:	111166003(KEAP1)

PCAD:

102986928(KEAP1)

PSIU:

116751263(KEAP1)

NASI:

112400167(KEAP1)

ECB:	100055128(KEAP1)

EPZ:	103562410(KEAP1)

EAI:	106846624(KEAP1)

MYB:	102247995(KEAP1)

MYD:	102753596(KEAP1)

MMYO:

118658140(KEAP1) 118663270

MLF:	102432374(KEAP1)

MDT:	132235059(KEAP1)

MYUM:

139010938(KEAP1)

PKL:	118731201(KEAP1)

EFUS:

103301129(KEAP1)

MNA:	107533297(KEAP1)

DRO:	112301530(KEAP1)

AJM:	119055679(KEAP1)

PDIC:

114502426(KEAP1)

PHAS:

123828183(KEAP1)

MMF:	118615462(KEAP1)

PPAM:

129061548(KEAP1)

HAI:	109391648(KEAP1)

RFQ:	117037884(KEAP1)

PALE:

102894870(KEAP1)

PGIG:

120610863(KEAP1)

PVP:	105305601(KEAP1)

RAY:	107515092(KEAP1)

MJV:	108383556(KEAP1)

TOD:	119240948(KEAP1)

SARA:

101540674(KEAP1)

SFUM:

130028992(KEAP1)

SETR:

126030288(KEAP1)

LAV:	100662208(KEAP1)

TMU:

101356221

ETF:	101663172(KEAP1)

DNM:	101429094(KEAP1)

MDO:	100012710(KEAP1)

GAS:	123232052(KEAP1)

SHR:	100927230(KEAP1)

AFZ:

127544731

PCW:	110214232(KEAP1)

TVP:	118828234(KEAP1)

PBRV:

138157479(KEAP1)

OAA:	100089243(KEAP1)

TACU:

119949304(KEAP1)

GGA:	100858752(KEAP1)

PCOC:

116241684

MGP:	104917088(KEAP1)

ACYG:

136788255(KEAP1)

TGU:	115491723(KEAP1)

PMOA:

120504943(KEAP1)

OTC:	121347831(KEAP1)

ATRC:

139585937(KEAP1)

PHI:	102101438(KEAP1)

CCW:	120412242(KEAP1)

ACOE:

138100163(KEAP1)

ZLE:	135442004(KEAP1)

SVG:	106863686(KEAP1)

HRT:	120748309(KEAP1)

SATI:

136375066(KEAP1)

CCIC:

134055463(KEAP1)

FPG:	101913139(KEAP1)

FCH:	102055868(KEAP1)

SHAB:

115603392(KEAP1)

ACHC:

115338389(KEAP1)

AGEN:

126043022

HHAR:

128138320(KEAP1)

NNI:	104013843(KEAP1)

CLV:	102089090(KEAP1)

CUCA:

104060261(KEAP1)

CVF:	104282683(KEAP1)

AAM:	106485710(KEAP1)

AROW:

112967168(KEAP1)

ASN:	102385105(KEAP1)

AMJ:	102575363(KEAP1)

GGN:	109291652(KEAP1)

CMY:	102940504(KEAP1)

CCAY:

125627386(KEAP1)

DCC:	119846011(KEAP1)

CPIC:

101953638(KEAP1)

CABI:

116824843(KEAP1)

MRV:	120390955(KEAP1)

ACS:	100568087(keap1)

ASAO:

132768049(KEAP1)

PVT:	110081732(KEAP1)

SUND:

121921510(KEAP1)

PBI:	103056705(KEAP1)

PMUR:

107285715(KEAP1)

CTIG:

120297129(KEAP1)

TSR:	106550853(KEAP1)

PGUT:

117675577(KEAP1)

APRI:

131191422(KEAP1)

PTEX:

113443273(KEAP1)

NSS:	113421534(KEAP1)

VKO:	123029997(KEAP1)

PMUA:

114587503(KEAP1)

PRAF:

128404729(KEAP1)

ZVI:	118097827(KEAP1)

HCG:	128346339(KEAP1)

GJA:	107122756(KEAP1)

STOW:

125429108(KEAP1)

EMC:	129346357(KEAP1)

XLA:	108706903 108713230 108713336(keap1.S) 496326(keap1.L)

XTR:	100489128 493386(keap1)

NPR:	108787832 108803810(KEAP1)

RTEM:

120913054 120933292(KEAP1)

BBUF:

120986395(KEAP1) 120989502

BGAR:

122927189(KEAP1) 122931000

PWL:	138267749 138292932(KEAP1)

MUO:	115466063(KEAP1) 115480034

GSH:	117349514(KEAP1) 117365801

DRE:	100003679(keap1b) 321837(keap1a)

SRX:	107705929(keap1) 107721712 107749088

SANH:

107678690 107690048 107694582(keap1)

SGH:	107568396(keap1) 107588875 107602621

CCAR:

109053857(keap1b) 109054162 109111365

CAUA:

113045136 113072332(keap1) 113120194

CGIB:

127934133 127951117 128015322

PTET:

122333305(keap1b) 122360377(keap1a)

LROH:

127166819(keap1b) 127178182(keap1a)

OMC:	131523988(keap1a) 131542684(keap1b)

PPRM:

120465111(keap1a) 120467907(keap1b) 120467908

RKG:	130070221(keap1a) 130100559(keap1b)

MAMB:

125250058(keap1a) 125274051(keap1b)

CIDE:

127497150 127514231 127524587

CERY:

137002833(keap1a) 137010628(keap1b)

MASI:

127441530 127442461 127446254 127449191

TROS:

130554975(keap1a) 130556726(keap1b)

TDW:	130417715(keap1a) 130425205(keap1b)

MANU:

129442885(keap1a) 129450465(keap1b)

PDAB:

135720769 135748683(keap1a) 135783271

IPU:	108268010(keap1a) 108273170(keap1b)

IFU:	128609673(keap1a) 128615719(keap1b)

PHYP:

113538294(keap1) 113540543

SMEO:

124384121(keap1b) 124387770(keap1a)

TFD:	113634484(keap1b) 113644088(keap1a)

TVC:	132844877(keap1b) 132848291(keap1a)

CGAR:

128522874(keap1a) 128526471(keap1b)

NGRA:

132884864(keap1b) 132891660(keap1a)

TRN:	134312121(keap1a) 134317103(keap1b)

AMEX:

103040234(keap1a) 103045265(keap1b)

CMAO:

118807904(keap1b) 118825492(keap1a)

EEE:	113579420(keap1) 113584252

CHAR:

105907002(keap1a) 105910173(keap1b)

SPIL:

134061403(keap1a) 134093607(keap1b)

TRU:	101063192 101073020(keap1)

TFS:	130526990(keap1b) 130540400(keap1a)

TNG:	GSTEN00007890G001 GSTEN00031936G001

LCO:	104926589 104926663(keap1)

NCC:	104943324(keap1) 104965954

TBEN:

117476776(keap1a) 117482011(keap1b)

CGOB:

115008857(keap1) 115027804

PGEO:

117446201(keap1b) 117467623(keap1a)

GACU:

117537918(keap1b) 117540617(keap1a)

EMAC:

134864483(keap1b) 134881738(keap1a)

ELY:	117255169(keap1b) 117267125(keap1a)

EFO:	125884460(keap1b) 125900690(keap1a)

PLEP:

121942034(keap1b) 121953530(keap1a)

SLUC:

116040459(keap1b) 116057474(keap1a)

ECRA:

117935832(keap1a) 117951368(keap1b)

ESP:	116669874 116695001(keap1)

PFLV:

114546874 114567260(keap1)

GAT:	120825092(keap1b) 120833073(keap1a)

PPUG:

119218190(keap1b) 119227908(keap1a)

AFB:	129096241(keap1b) 129103572(keap1a)

CLUM:

117730578(keap1b) 117751184(keap1a)

PSWI:

130190109(keap1b) 130201414(keap1a)

CANA:

137799619(keap1b) 137802551(keap1a)

CVE:	137884854(keap1b)

MSAM:

119899192(keap1b) 119910159(keap1a)

SCHU:

122862081(keap1a) 122873204(keap1b)

CUD:	121508373(keap1b) 121526459(keap1a)

SPUL:

138591022(keap1a) 138594766(keap1b)

LMIX:

132991674(keap1b) 132992979(keap1a)

ALAT:

119004713(keap1a) 119021657(keap1b)

ASTR:

137600163(keap1b) 137610972(keap1a)

MZE:	101465797 101473586(keap1)

ONL:	100710656 100711842(keap1)

OAU:	116321346(keap1b) 116326044(keap1a)

OLA:	101159396 101160787(keap1)

OML:	112149919(keap1a) 112157092(keap1b)

CSAI:

133427924(keap1b) 133462912(keap1a)

XMA:	102226304 102236560(keap1)

XCO:	114134410 114144048(keap1)

XHE:	116709247 116719769(keap1)

PRET:

103458467 103468321(keap1)

PFOR:

103137721(keap1) 103156371

PLAI:

106953027 106959722(keap1)

PMEI:

106914672(keap1) 106929737

GAF:	122829453(keap1b) 122846291(keap1a)

PPRL:

129365297(keap1a)

CVG:	107093029 107100428(keap1)

CTUL:

119775560(keap1a) 119788231(keap1b)

GMU:	124855944(keap1a) 124868298(keap1b)

NFU:	107382244(keap1) 107392120

KMR:	108232145(keap1a) 108244352(keap1b)

ALIM:

106515241(keap1) 106518474

NWH:	119407588(keap1b) 119427831(keap1a)

AOCE:

111570165(keap1b) 111582902(keap1a)

EJA:	138200119(keap1a) 138208714(keap1b)

BFRE:

138620266(keap1b) 138627942(keap1a)

MCEP:

125003832(keap1b) 125024051(keap1a)

CSEM:

103380129 103384180(keap1)

POV:	109627615(keap1) 109636224

SSEN:

122771644(keap1b) 122783185(keap1a)

SSOE:

131445086(keap1a) 131467417(keap1b)

HHIP:

117755725(keap1a) 117766871(keap1b)

HSP:	118116816(keap1a) 118118125(keap1b)

PPLT:

128436592(keap1b) 128450426(keap1a)

SMAU:

118286355(keap1a) 118312283(keap1b)

LCF:	108875034 108875866(keap1b)

SDU:	111226197 111237672(keap1)

SLAL:

111664555(keap1) 111670163

XGL:	120795651(keap1a) 120800340(keap1b)

HCQ:	109511223(keap1) 109517426

SSCV:

125969218(keap1b) 125980999(keap1a)

SBIA:

133506148(keap1b) 133513429(keap1a)

PEE:	133403770(keap1b) 133412542(keap1a)

PTAO:

133477118(keap1b) 133487595(keap1a)

BPEC:

110172628(keap1)

MALB:

109958431(keap1) 109968064

BSPL:

114848452(keap1a) 114857003(keap1b)

SJO:	128368105(keap1b) 128375269(keap1a)

SSCO:

133991053(keap1b) 134000597(keap1a)

GMH:	115541079(keap1) 115544122

SASA:

106564503 106574506 106590064

STRU:

115147367 115178771 115196157

OTW:	112230202(keap1b) 112267684(keap1a) 121840576

OMY:	110485638(keap1b) 110495743(keap1a) 118938209

OGO:	124011275(keap1a) 124015161(keap1b)

ONE:	115127279(keap1)

OKI:	109865841 109877408 109879738

OKE:	118363195(keap1a) 118389428

OMM:	135535583(keap1b) 135543423(keap1a)

OCLA:

139373120 139402008 139402020

SALP:

111953544 112076012

SNH:	120032831(keap1b) 120033565(keap1a)

CCLU:

121554009(keap1b) 121560171(keap1a)

ELS:	105012141(keap1) 105019872

SFM:	108921418 108940127(keap1)

PKI:	111833557(keap1) 111836584

AANG:

118221063(keap1b) 118230239(keap1a)

AROT:

135248910(keap1b) 135251334(keap1a)

CCOG:

133121502(keap1b) 133129451(keap1a)

LOC:	102687960(keap1) 102689289

PSPA:

121300992 121301536 121309156(keap1b)

ARUT:

117401476 117402049 117962286 117966873

PSEX:

120538257(keap1a) 120541234(keap1b)

LCM:	102349551(KEAP1) 102358487

CMK:	103182030(keap1a) 103188845(keap1b)

RTP:	109919574(keap1b) 109923446(keap1a)

CPLA:

122554516(keap1b) 122565496(keap1a)

HOC:	132819009 132828982

LERI:

129701227(keap1b) 129711051(keap1a)

PMRN:

116943673(KEAP1)

LRJ:

133346518

BFO:	118429928 118432005

BBEL:

109483593

CIN:

100177101

SCLV:

120343570

SPU:	100889922 115928597

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG3962(Keap1)

DER:

6552237

DSE:

6616797

DSI:	Dsimw501_GD20252(Dsim_GD20252)

DYA:	Dyak_GE26109

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23743

DAZ:

108608862

DNV:

108649767

DHE:

111602537

DVI:	6632652(Keap1)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119676708 119681355

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135963244(Keap1)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ007653

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139107986(Keap1)

TLN:	139814393(Keap1)

HST:

DQU:

CFO:

FEX:

PMEC:

138939024(Keap1)

LHU:	105675225(Keap1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124217654(Keap1)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138125568(Keap1)

DPA:

109545476

ESIM:

136409960(Keap1)

EFOR:

136343240(Keap1)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

116168203 116175970 116182682

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207551

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137930817(Keap1)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

AGS:

CLEC:

HHAL:

106681660(Keap1)

HVI:	124352791 124369560

MQU:	128994926 129004734

PHU:	Phum_PHUM424490

FOC:

113210352

TPAL:

117644483 117645200 117652854

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139690164(Keap1)

DPX:	DAPPUDRAFT_312845

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128697717(Keap1)

PTRU:

123509883

ESN:

127007794

MNZ:

135198591

MRJ:	136851591(Keap1)

PORN:

139761344

HAZT:

108667394

PPOI:

119111487

DSV:	119432686 119433042 119433420

RSAN:

119378575 119404731 119405291

RMP:	119180546 119181622

VDE:

111244000

VJA:

111260883

CSCU:

111629014

CVS:	136977128(Keap1)

PTEP:

107453472

ABRU:

129984078

UDV:

129224469

SDM:	118181067 118201906

LPOL:

106458776

PMEO:

129593059

LGI:	LOTGIDRAFT_157498

PVUL:

126817147

PCAN:

112573324

LSAX:

138966029

BGT:	106060440 106063973

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:	135470518 135470842

LAK:	106151256 106174131

SMM:	Smp_085380

SHX:	MS3_00004235(KEAP1)

EGL:

EGR_00710

LLON:

135486904

ADF:	107335531 107357696 107357697

AMIL:

114975094

MCAZ:

138024884

MFOO:

137973578 137989082 137992296

SPIS:

111342357 111344242 111347673

DGT:

XEN:

HMG:

HSY:

RES:

Reference

PMID:15601839

Authors

Furukawa M, Xiong Y.

Title

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.

Journal

Mol Cell Biol 25:162-71 (2005)
DOI:10.1128/MCB.25.1.162-171.2005

Sequence

[hsa:9817]

Reference

PMID:9887101

Authors

Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M

Title

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

Journal

Genes Dev 13:76-86 (1999)
DOI:10.1101/gad.13.1.76

Sequence

[mmu:50868]

LinkDB

DBGET integrated database retrieval system

pFad - (p)hone/(F)rame/(a)nonymizer/(d)eclutterfier! Saves Data!