KEGG T01001: 1499

Homo sapiens (human): 1499

Entry

1499              CDS       T01001

Symbol

CTNNB1, CTNNB, EVR7, MRD19, NEDSDV, armadillo

Name

(RefSeq) catenin beta 1

K02105

catenin beta 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04015

Rap1 signaling pathway

hsa04310

Wnt signaling pathway

hsa04390

Hippo signaling pathway

hsa04510

Focal adhesion

hsa04520

Adherens junction

hsa04550

Signaling pathways regulating pluripotency of stem cells

hsa04670

Leukocyte transendothelial migration

hsa04916

Melanogenesis

hsa04919

Thyroid hormone signaling pathway

hsa04934

Cushing syndrome

hsa04936

Alcoholic liver disease

hsa05010

Alzheimer disease

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05100

Bacterial invasion of epithelial cells

hsa05132

Salmonella infection

hsa05160

Hepatitis C

hsa05163

Human cytomegalovirus infection

hsa05165

Human papillomavirus infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05200

Pathways in cancer

hsa05205

Proteoglycans in cancer

hsa05210

Colorectal cancer

hsa05213

Endometrial cancer

hsa05215

Prostate cancer

hsa05216

Thyroid cancer

hsa05217

Basal cell carcinoma

hsa05224

Breast cancer

hsa05225

Hepatocellular carcinoma

hsa05226

Gastric cancer

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

hsa05418

Fluid shear stress and atherosclerosis

Network

nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181  Salmonella
nt06215  WNT signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06505  WNT signaling

Element

N00056

Wnt signaling pathway

N00057

Mutation-inactivated APC to Wnt signaling pathway

N00058

Mutation-activated CTNNB1 to Wnt signaling pathway

N00059

FZD7-overexpression to Wnt signaling pathway

N00060

LRP6-overexpression to Wnt signaling pathway

N00061

CDH1-reduced expression to beta-catenin signaling pathway

N00175

KSHV LANA to Wnt signaling pathway

N00242

Mutation-inactivated AXIN to Wnt signaling pathway

N00257

Loss of CDH1 to beta-catenin signaling pathway

N00258

Mutation-inactivated CDH1 to beta-catenin signaling pathway

N01124

Salmonella AvrA to beta-catenin signaling pathway

Disease

H00018

Gastric cancer

H00020

Colorectal cancer

H00026

Endometrial cancer

H00027

Ovarian cancer

H00032

Thyroid cancer

H00048

Hepatocellular carcinoma

H00589

Familial exudative vitreoretinopathy

H00773

Autosomal dominant intellectual developmental disorder

H00947

Pilomatricoma

H01667

Medulloblastoma

H02301

Nephroblastoma

H02302

Hepatoblastoma

Drug target

Foscenvivint:

D12445

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    1499 (CTNNB1)
   04310 Wnt signaling pathway
    1499 (CTNNB1)
   04390 Hippo signaling pathway
    1499 (CTNNB1)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    1499 (CTNNB1)
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    1499 (CTNNB1)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    1499 (CTNNB1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1499 (CTNNB1)
   05205 Proteoglycans in cancer
    1499 (CTNNB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    1499 (CTNNB1)
   05225 Hepatocellular carcinoma
    1499 (CTNNB1)
   05226 Gastric cancer
    1499 (CTNNB1)
   05216 Thyroid cancer
    1499 (CTNNB1)
   05217 Basal cell carcinoma
    1499 (CTNNB1)
   05215 Prostate cancer
    1499 (CTNNB1)
   05213 Endometrial cancer
    1499 (CTNNB1)
   05224 Breast cancer
    1499 (CTNNB1)
  09172 Infectious disease: viral
   05160 Hepatitis C
    1499 (CTNNB1)
   05163 Human cytomegalovirus infection
    1499 (CTNNB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1499 (CTNNB1)
   05165 Human papillomavirus infection
    1499 (CTNNB1)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    1499 (CTNNB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1499 (CTNNB1)
   05022 Pathways of neurodegeneration - multiple diseases
    1499 (CTNNB1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1499 (CTNNB1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    1499 (CTNNB1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    1499 (CTNNB1)
   04934 Cushing syndrome
    1499 (CTNNB1)

SSDB

Motif

Pfam:

Arm ARM_ARMC5 Cnd1 HEAT_2 HEAT_EZ Adaptin_N KAP ARMC9_ARM Atx10homo_assoc Queuosine_synth

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

3:41199505..41240443

AA seq 781 aa
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L

NT seq 2346 nt +upstreamnt +downstreamnt
atggctactcaagctgatttgatggagttggacatggccatggaaccagacagaaaagcg
gctgttagtcactggcagcaacagtcttacctggactctggaatccattctggtgccact
accacagctccttctctgagtggtaaaggcaatcctgaggaagaggatgtggatacctcc
caagtcctgtatgagtgggaacagggattttctcagtccttcactcaagaacaagtagct
gatattgatggacagtatgcaatgactcgagctcagagggtacgagctgctatgttccct
gagacattagatgagggcatgcagatcccatctacacagtttgatgctgctcatcccact
aatgtccagcgtttggctgaaccatcacagatgctgaaacatgcagttgtaaacttgatt
aactatcaagatgatgcagaacttgccacacgtgcaatccctgaactgacaaaactgcta
aatgacgaggaccaggtggtggttaataaggctgcagttatggtccatcagctttctaaa
aaggaagcttccagacacgctatcatgcgttctcctcagatggtgtctgctattgtacgt
accatgcagaatacaaatgatgtagaaacagctcgttgtaccgctgggaccttgcataac
ctttcccatcatcgtgagggcttactggccatctttaagtctggaggcattcctgccctg
gtgaaaatgcttggttcaccagtggattctgtgttgttttatgccattacaactctccac
aaccttttattacatcaagaaggagctaaaatggcagtgcgtttagctggtgggctgcag
aaaatggttgccttgctcaacaaaacaaatgttaaattcttggctattacgacagactgc
cttcaaattttagcttatggcaaccaagaaagcaagctcatcatactggctagtggtgga
ccccaagctttagtaaatataatgaggacctatacttacgaaaaactactgtggaccaca
agcagagtgctgaaggtgctatctgtctgctctagtaataagccggctattgtagaagct
ggtggaatgcaagctttaggacttcacctgacagatccaagtcaacgtcttgttcagaac
tgtctttggactctcaggaatctttcagatgctgcaactaaacaggaagggatggaaggt
ctccttgggactcttgttcagcttctgggttcagatgatataaatgtggtcacctgtgca
gctggaattctttctaacctcacttgcaataattataagaacaagatgatggtctgccaa
gtgggtggtatagaggctcttgtgcgtactgtccttcgggctggtgacagggaagacatc
actgagcctgccatctgtgctcttcgtcatctgaccagccgacaccaagaagcagagatg
gcccagaatgcagttcgccttcactatggactaccagttgtggttaagctcttacaccca
ccatcccactggcctctgataaaggctactgttggattgattcgaaatcttgccctttgt
cccgcaaatcatgcacctttgcgtgagcagggtgccattccacgactagttcagttgctt
gttcgtgcacatcaggatacccagcgccgtacgtccatgggtgggacacagcagcaattt
gtggagggggtccgcatggaagaaatagttgaaggttgtaccggagcccttcacatccta
gctcgggatgttcacaaccgaattgttatcagaggactaaataccattccattgtttgtg
cagctgctttattctcccattgaaaacatccaaagagtagctgcaggggtcctctgtgaa
cttgctcaggacaaggaagctgcagaagctattgaagctgagggagccacagctcctctg
acagagttacttcactctaggaatgaaggtgtggcgacatatgcagctgctgttttgttc
cgaatgtctgaggacaagccacaagattacaagaaacggctttcagttgagctgaccagc
tctctcttcagaacagagccaatggcttggaatgagactgctgatcttggacttgatatt
ggtgcccagggagaaccccttggatatcgccaggatgatcctagctatcgttcttttcac
tctggtggatatggccaggatgccttgggtatggaccccatgatggaacatgagatgggt
ggccaccaccctggtgctgactatccagttgatgggctgccagatctggggcatgcccag
gacctcatggatgggctgcctccaggtgacagcaatcagctggcctggtttgatactgac
ctgtaa

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