KEGG T01001: 3481

Homo sapiens (human): 3481

Entry

3481              CDS       T01001

Symbol

IGF2, C11orf43, GRDF, IGF-II, PP9974, SRS3

Name

(RefSeq) insulin like growth factor 2

K13769

insulin-like growth factor 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04081

Hormone signaling

hsa04151

PI3K-Akt signaling pathway

hsa05200

Pathways in cancer

hsa05205

Proteoglycans in cancer

hsa05225

Hepatocellular carcinoma

Network

nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06324  GHRH-GH-IGF signaling
nt06526  MAPK signaling
nt06530  PI3K signaling

Element

N00233

IGF-IGF1R-RAS-ERK signaling pathway

N00234

IGF2-IGF1R-PI3K signaling pathway

N00235

IGF2-overexpression to RAS-ERK signaling pathway

N00236

IGF2-overexpression to PI3K signaling pathway

N00237

IGF1R-overexpression to RAS-ERK signaling pathway

N00238

IGF1R-overexpression to PI3K signaling pathway

N01592

GF-RTK-RAS-ERK signaling pathway

N01656

GF-RTK-PI3K signaling pathway

N01658

GF-RTK-RAS-PI3K signaling pathway

Disease

H00033

Adrenal carcinoma

H00048

Hepatocellular carcinoma

H00711

Russell-Silver syndrome

H00713

Beckwith-Wiedemann syndrome

Drug target

Dusigitumab:

D10352

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    3481 (IGF2)
   04151 PI3K-Akt signaling pathway
    3481 (IGF2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    3481 (IGF2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3481 (IGF2)
   05205 Proteoglycans in cancer
    3481 (IGF2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    3481 (IGF2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3481 (IGF2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3481 (IGF2)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Growth factors (RTK binding)
   3481 (IGF2)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   3481 (IGF2)

SSDB

Motif

Pfam:

IGF2_C Insulin

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

CPD:

UniProt:

Structure

LinkDB

Position

11:complement(2129117..2149566)

AA seq 180 aa
MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVS
RRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWK
QSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK

NT seq 543 nt +upstreamnt +downstreamnt
atgggaatcccaatggggaagtcgatgctggtgcttctcaccttcttggccttcgcctcg
tgctgcattgctgcttaccgccccagtgagaccctgtgcggcggggagctggtggacacc
ctccagttcgtctgtggggaccgcggcttctacttcagcaggcccgcaagccgtgtgagc
cgtcgcagccgtggcatcgttgaggagtgctgtttccgcagctgtgacctggccctcctg
gagacgtactgtgctacccccgccaagtccgagagggacgtgtcgacccctccgaccgtg
cttccggacaacttccccagataccccgtgggcaagttcttccaatatgacacctggaag
cagtccacccagcgcctgcgcaggggcctgcctgccctcctgcgtgcccgccggggtcac
gtgctcgccaaggagctcgaggcgttcagggaggccaaacgtcaccgtcccctgattgct
ctacccacccaagaccccgcccacgggggcgcccccccagagatggccagcaatcggaag
tga

DBGET integrated database retrieval system

pFad - (p)hone/(F)rame/(a)nonymizer/(d)eclutterfier! Saves Data!