KEGG T01001: 4780

Homo sapiens (human): 4780

Entry

4780              CDS       T01001

Symbol

NFE2L2, HEBP1, IMDDHH, NRF2, Nrf-2

Name

(RefSeq) NFE2 like bZIP transcription factor 2

K05638

nuclear factor erythroid 2-related factor 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04141

Protein processing in endoplasmic reticulum

hsa05012

Parkinson disease

hsa05200

Pathways in cancer

hsa05208

Chemical carcinogenesis - reactive oxygen species

hsa05225

Hepatocellular carcinoma

hsa05417

Lipid and atherosclerosis

hsa05418

Fluid shear stress and atherosclerosis

Network

nt06226  KEAP1-NRF2 signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease

Element

N00243

KEAP1-NRF2 signaling pathway

N00244

Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway

N00245

Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway

N01059

Mutation-inactivated DJ1 to KEAP1-NRF2 signaling pathway

N01413

Metals to KEAP1-NRF2 signalig pathway

Disease

H00048

Hepatocellular carcinoma

Drug target

Omaveloxolone:

D10964<US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    4780 (NFE2L2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    4780 (NFE2L2)
   05208 Chemical carcinogenesis - reactive oxygen species
    4780 (NFE2L2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    4780 (NFE2L2)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    4780 (NFE2L2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    4780 (NFE2L2)
   05418 Fluid shear stress and atherosclerosis
    4780 (NFE2L2)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    4780 (NFE2L2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4780 (NFE2L2)
Transcription factors [BR:hsa03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, NF-E2
    4780 (NFE2L2)
Mitochondrial biogenesis [BR:hsa03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Nuclear respiratory factors
    4780 (NFE2L2)

SSDB

Motif

Pfam:

bZIP_Maf bZIP_1 bZIP_2 T3SS_basalb_I PNISR

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

2:complement(177230303..177264727)

AA seq 605 aa
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN

NT seq 1818 nt +upstreamnt +downstreamnt
atgatggacttggagctgccgccgccgggactcccgtcccagcaggacatggatttgatt
gacatactttggaggcaagatatagatcttggagtaagtcgagaagtatttgacttcagt
cagcgacggaaagagtatgagctggaaaaacagaaaaaacttgaaaaggaaagacaagaa
caactccaaaaggagcaagagaaagcctttttcgctcagttacaactagatgaagagaca
ggtgaatttctcccaattcagccagcccagcacatccagtcagaaaccagtggatctgcc
aactactcccaggttgcccacattcccaaatcagatgctttgtactttgatgactgcatg
cagcttttggcgcagacattcccgtttgtagatgacaatgaggtttcttcggctacgttt
cagtcacttgttcctgatattcccggtcacatcgagagcccagtcttcattgctactaat
caggctcagtcacctgaaacttctgttgctcaggtagcccctgttgatttagacggtatg
caacaggacattgagcaagtttgggaggagctattatccattcctgagttacagtgtctt
aatattgaaaatgacaagctggttgagactaccatggttccaagtccagaagccaaactg
acagaagttgacaattatcatttttactcatctataccctcaatggaaaaagaagtaggt
aactgtagtccacattttcttaatgcttttgaggattccttcagcagcatcctctccaca
gaagaccccaaccagttgacagtgaactcattaaattcagatgccacagtcaacacagat
tttggtgatgaattttattctgctttcatagctgagcccagtatcagcaacagcatgccc
tcacctgctactttaagccattcactctctgaacttctaaatgggcccattgatgtttct
gatctatcactttgcaaagctttcaaccaaaaccaccctgaaagcacagcagaattcaat
gattctgactccggcatttcactaaacacaagtcccagtgtggcatcaccagaacactca
gtggaatcttccagctatggagacacactacttggcctcagtgattctgaagtggaagag
ctagatagtgcccctggaagtgtcaaacagaatggtcctaaaacaccagtacattcttct
ggggatatggtacaacccttgtcaccatctcaggggcagagcactcacgtgcatgatgcc
caatgtgagaacacaccagagaaagaattgcctgtaagtcctggtcatcggaaaacccca
ttcacaaaagacaaacattcaagccgcttggaggctcatctcacaagagatgaacttagg
gcaaaagctctccatatcccattccctgtagaaaaaatcattaacctccctgttgttgac
ttcaacgaaatgatgtccaaagagcagttcaatgaagctcaacttgcattaattcgggat
atacgtaggaggggtaagaataaagtggctgctcagaattgcagaaaaagaaaactggaa
aatatagtagaactagagcaagatttagatcatttgaaagatgaaaaagaaaaattgctc
aaagaaaaaggagaaaatgacaaaagccttcacctactgaaaaaacaactcagcacctta
tatctcgaagttttcagcatgctacgtgatgaagatggaaaaccttattctcctagtgaa
tactccctgcagcaaacaagagatggcaatgttttccttgttcccaaaagtaagaagcca
gatgttaagaaaaactag

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