| Entry |
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| Symbol |
RB1, OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb, pp110
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| Name |
(RefSeq) RB transcriptional corepressor 1
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| KO |
| K06618 | retinoblastoma-associated protein |
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| Organism |
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| Pathway |
| hsa05163 | Human cytomegalovirus infection |
| hsa05166 | Human T-cell leukemia virus 1 infection |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
| hsa05207 | Chemical carcinogenesis - receptor activation |
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| Network |
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| Element |
| N00066 | MDM2-p21-Cell cycle G1/S |
| N00067 | Deleted p14(ARF) to p21-cell cycle G1/S |
| N00068 | Amplified MDM2 to p21-cell cycle G1/S |
| N00070 | Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S |
| N00071 | Deleted p16(INK4a) to p16-cell cycle G1/S |
| N00072 | Amplified CDK4 to cell cycle G1/S |
| N00073 | Mutation-activated CDK4 to cell cycle G1/S |
| N00074 | Loss of RB1 to cell cycle G1/S |
| N00075 | Mutation-inactivated RB1 to cell cycle G1/S |
| N00076 | Mutation-inactivated p14(ARF) to p21-cell cycle G1/S |
| N00088 | Amplified MYC to p15-cell cycle G1/S |
| N00089 | Amplified MYC to cell cycle G1/S |
| N00092 | Amplified MYC to p27-cell cycle G1/S |
| N00093 | Loss of CDKN1B to p27-cell cycle G1/S |
| N00168 | KSHV vCyclin to cell cycle G1/S |
| N00170 | KSHV LANA to cell cycle G1/S |
| N00254 | CDKN1B-reduced expression to p27-cell cycle G1/S |
| N00255 | Amplified CCNE to cell cycle G1/S |
| N00264 | EBV EBNA3C to p27-Cell cycle G1/S |
| N00275 | Amplified CCND1 to cell cycle G1/S |
| N00316 | Mutation-inactivated CDKN1B to p27-cell cycle G1/S |
| N00347 | p300-p21-Cell cycle G1/S |
| N00360 | HPV E7 to p27-cell cycle G1/S |
| N00361 | HPV E7 to cell cycle G1/S |
| N00365 | HPV E7 to cell cycle G1/S |
| N00422 | HCMV IE2-86 to cell cycle G1/S |
| N00423 | HCMV IE1-72 to cell cycle G1/S |
| N00424 | HCMV pp71 to cell cycle G1/S |
| N00482 | EBV EBNA3C to p27-Cell cycle G1/S |
| N00483 | EBV EBNA3C to cell cycle G1/S |
| N00484 | EBV EBNA3C to cell cycle G1/S |
| N00497 | HTLV-1 Tax to p21-cell cycle G1/S |
| N00498 | HTLV-1 Tax to p21-cell cycle G1/S |
| N00536 | MDM2-p21-Cell cycle G1/S |
| N00537 | HBV HBx to cell cycle G1/S |
| N01336 | CHRNA7-E2F signaling pathway |
| N01337 | NNK/NNN to CHRNA7-E2F signaling pathway |
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| Disease |
| H00004 | Chronic myeloid leukemia |
| H00048 | Hepatocellular carcinoma |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5925 (RB1)
05207 Chemical carcinogenesis - receptor activation
5925 (RB1)
05203 Viral carcinogenesis
5925 (RB1)
09162 Cancer: specific types
05212 Pancreatic cancer
5925 (RB1)
05225 Hepatocellular carcinoma
5925 (RB1)
05226 Gastric cancer
5925 (RB1)
05214 Glioma
5925 (RB1)
05220 Chronic myeloid leukemia
5925 (RB1)
05218 Melanoma
5925 (RB1)
05219 Bladder cancer
5925 (RB1)
05215 Prostate cancer
5925 (RB1)
05224 Breast cancer
5925 (RB1)
05222 Small cell lung cancer
5925 (RB1)
05223 Non-small cell lung cancer
5925 (RB1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
5925 (RB1)
05161 Hepatitis B
5925 (RB1)
05160 Hepatitis C
5925 (RB1)
05163 Human cytomegalovirus infection
5925 (RB1)
05167 Kaposi sarcoma-associated herpesvirus infection
5925 (RB1)
05169 Epstein-Barr virus infection
5925 (RB1)
05165 Human papillomavirus infection
5925 (RB1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
5925 (RB1)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
5925 (RB1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:hsa01009]
5925 (RB1)
09182 Protein families: genetic information processing
03000 Transcription factors [BR:hsa03000]
5925 (RB1)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
5925 (RB1)
Transcription factors [BR:hsa03000]
Eukaryotic type
Other transcription factors
Pocket domain Rb
5925 (RB1)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
13:48303751..48481890
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| AA seq |
928 aa
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTAL
CQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTEL
QKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYK
TAVIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFM
NSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
NLDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVK
DIGYIFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDN
IFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEG
NLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNH
TAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYL
RLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLK
FKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLS
PIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFG
TSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQK
LAEMTSTRTRMQKQKMNDSMDTSNKEEK |
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| NT seq |
2787 nt +upstreamnt +downstreamnt
atgccgcccaaaaccccccgaaaaacggccgccaccgccgccgctgccgccgcggaaccc
ccggcaccgccgccgccgccccctcctgaggaggacccagagcaggacagcggcccggag
gacctgcctctcgtcaggcttgagtttgaagaaacagaagaacctgattttactgcatta
tgtcagaaattaaagataccagatcatgtcagagagagagcttggttaacttgggagaaa
gtttcatctgtggatggagtattgggaggttatattcaaaagaaaaaggaactgtgggga
atctgtatctttattgcagcagttgacctagatgagatgtcgttcacttttactgagcta
cagaaaaacatagaaatcagtgtccataaattctttaacttactaaaagaaattgatacc
agtaccaaagttgataatgctatgtcaagactgttgaagaagtatgatgtattgtttgca
ctcttcagcaaattggaaaggacatgtgaacttatatatttgacacaacccagcagttcg
atatctactgaaataaattctgcattggtgctaaaagtttcttggatcacatttttatta
gctaaaggggaagtattacaaatggaagatgatctggtgatttcatttcagttaatgcta
tgtgtccttgactattttattaaactctcacctcccatgttgctcaaagaaccatataaa
acagctgttatacccattaatggttcacctcgaacacccaggcgaggtcagaacaggagt
gcacggatagcaaaacaactagaaaatgatacaagaattattgaagttctctgtaaagaa
catgaatgtaatatagatgaggtgaaaaatgtttatttcaaaaattttataccttttatg
aattctcttggacttgtaacatctaatggacttccagaggttgaaaatctttctaaacga
tacgaagaaatttatcttaaaaataaagatctagatgcaagattatttttggatcatgat
aaaactcttcagactgattctatagacagttttgaaacacagagaacaccacgaaaaagt
aaccttgatgaagaggtgaatgtaattcctccacacactccagttaggactgttatgaac
actatccaacaattaatgatgattttaaattcagcaagtgatcaaccttcagaaaatctg
atttcctattttaacaactgcacagtgaatccaaaagaaagtatactgaaaagagtgaag
gatataggatacatctttaaagagaaatttgctaaagctgtgggacagggttgtgtcgaa
attggatcacagcgatacaaacttggagttcgcttgtattaccgagtaatggaatccatg
cttaaatcagaagaagaacgattatccattcaaaattttagcaaacttctgaatgacaac
atttttcatatgtctttattggcgtgcgctcttgaggttgtaatggccacatatagcaga
agtacatctcagaatcttgattctggaacagatttgtctttcccatggattctgaatgtg
cttaatttaaaagcctttgatttttacaaagtgatcgaaagttttatcaaagcagaaggc
aacttgacaagagaaatgataaaacatttagaacgatgtgaacatcgaatcatggaatcc
cttgcatggctctcagattcacctttatttgatcttattaaacaatcaaaggaccgagaa
ggaccaactgatcaccttgaatctgcttgtcctcttaatcttcctctccagaataatcac
actgcagcagatatgtatctttctcctgtaagatctccaaagaaaaaaggttcaactacg
cgtgtaaattctactgcaaatgcagagacacaagcaacctcagccttccagacccagaag
ccattgaaatctacctctctttcactgttttataaaaaagtgtatcggctagcctatctc
cggctaaatacactttgtgaacgccttctgtctgagcacccagaattagaacatatcatc
tggacccttttccagcacaccctgcagaatgagtatgaactcatgagagacaggcatttg
gaccaaattatgatgtgttccatgtatggcatatgcaaagtgaagaatatagaccttaaa
ttcaaaatcattgtaacagcatacaaggatcttcctcatgctgttcaggagacattcaaa
cgtgttttgatcaaagaagaggagtatgattctattatagtattctataactcggtcttc
atgcagagactgaaaacaaatattttgcagtatgcttccaccaggccccctaccttgtca
ccaatacctcacattcctcgaagcccttacaagtttcctagttcacccttacggattcct
ggagggaacatctatatttcacccctgaagagtccatataaaatttcagaaggtctgcca
acaccaacaaaaatgactccaagatcaagaatcttagtatcaattggtgaatcattcggg
acttctgagaagttccagaaaataaatcagatggtatgtaacagcgaccgtgtgctcaaa
agaagtgctgaaggaagcaaccctcctaaaccactgaaaaaactacgctttgatattgaa
ggatcagatgaagcagatggaagtaaacatctcccaggagagtccaaatttcagcagaaa
ctggcagaaatgacttctactcgaacacgaatgcaaaagcagaaaatgaatgatagcatg
gatacctcaaacaaggaagagaaatga |
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