Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.

Characterizing the superconducting gap structure in the high-temperature superconductor H₃S by means of tunnelling spectroscopy reveals that it, as well as D₃S, has a fully gapped structure, confirming the phonon-mediated mechanism of superconducting pairing.

Using high-throughput functional profiling, how disordered regions control mRNA stability and translation is explored.

Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed between the hippocampus and hypothalamus that enables the recall of cold-related memories.

Atomic precision lift-off of ultrathin membranes without artificial release layers can be achieved to facilitate the high-throughput production of scalable, ultrathin, single-crystalline, freestanding perovskite systems.

Realistic-lithosphere numerical models suggest glacial forcing in the last glacial cycle notably affected plate motions and mid-ocean-ridge spreading rates near major ice sheets, with implications for modern polar deglaciation enhancing magmatism and markedly impacting climate.

A twin-field quantum key distribution protocol based on optical coherence is deployed over a 254-kilometre commercial telecom network, demonstrating that coherence-based quantum communication can be aligned with existing telecommunication infrastructure.

The core circadian transcription factor BMAL1 regulates circadian-dependent myocardial injury.

Generalization of a quantum twisting microscope to cryogenic temperatures in twisted bilayer graphene shows the ability to map phononic dispersions through inelastic momentum-conserving tunnelling and reveals an angle-dependent coupling between electrons and phonons.

ADP-heptose binds to ALPK1, triggering transcriptional reprogramming and NF-κB activation, endowing pre-leukaemic cells with a competitive advantage due to excessive clonal proliferation.

A versatile origami-inspired modular chiral mechanical metamaterial structure facilitates dual-mode actuation, converting compression into rotational motion and torsion into extension or compression.

3D seismic reflection images of the lithosphere–asthenosphere boundary beneath Axial volcano show a magma assimilation front that focuses magmatism towards the centre of the volcano, controlling both eruption and hydrothermal processes.

A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.

Characterization of the genetic architecture underlying the 7 pairs of contrasting traits studied by Mendel and the over 70 additional agronomic traits in pea (Pisum sativum) reveals their molecular details and provides tools for further studies in pea genetics, functional genomics and crop improvement.

Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set to understand the most fundamental processes underlying human genetic variation.

Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing pain, heat hypersensitivity and tactile allodynia during inflammation.

Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.

Levantine Phoenicians made little genetic contribution to Punic settlements in the central and western Mediterranean between the sixth and second centuries bce; instead, the Punic people derived most of their ancestry from a genetic profile similar to that of Sicily and the Aegean, with notable contributions from North Africa as well.