ConSTRain is a short tandem repeat caller allowing for the investigation of tumour heterogeneity and clonal lineage tracing in cancer, even in closely related samples.

The authors sequence and phenotype over 1,000 isolates of the yeast Brettanomyces bruxellensis, and show how allopolyploidization reshapes genome evolution and enhances phenotypic diversity, highlighting the role of acquired subgenomes.

The diversity and genomic resources of Brassicaceae make it an ideal model for studying karyotype evolution. Here, the authors reconstruct ancestral karyotypes of Camelinodae and Brassicodae, identify cascading fusions, and highlight their stable inheritance and role in evolutionary relationships.

In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its immediate benefits, persist under selection, and fuel long-term innovations via aneuploidy.

The polyploidy of mammalian cardiomyocytes is a barrier to heart regeneration, but modification of the cardiomyocyte cell cycle can boost their regenerative potential.

The polyploidy of mammalian cardiomyocytes is a barrier to heart regeneration, but modification of the cardiomyocyte cell cycle can boost their regenerative potential.

A detailed phylogenetic study now shows that there is a compelling association between polyploidy and domestication, and that polyploidy more frequently occurs before domestication.