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In silico approaches for study the therapeutic potential of Cannabis sativa (Bhang) against HIV

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Abstract

Human Immunodeficiency Virus (HIV) is one of the world's most significant public health issues. HIV become severe in the COVID pandemic. Scientists are investigating antivirals for HIV from phytoconstituents. Since the beginning of civilization, medicinal plants have played an important role in plentiful sources of nutrients and, healing of infection. The purpose of this in-silico study was to investigate the potential antiviral activity of metabolites from Cannabis sativa against HIV. The plant's active metabolites were retrieved, and molecular docking for 24 molecules was performed against the Protease, GP120, Integrase, and Reverse transcriptase proteins of the HIV, and their binding affinity compared with the existing drug. Results revealed that delta-cadenine, campestrol, beta-carotene and cannabinol showed the lowest binding energy for the proteins reverse transcriptase, protease, GP120, and Integrase when compared with their reference drugs respectively. Bhang is a potential therapeutic agent and provides alternative treatments to prompt, sensitive, cost-effective management of HIV.

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  1. Versha Kajal and Sanjit Boora: Joint Authorship.

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  1. Centre for Biotechnology, Maharshi Dayanand University, Rohtak, Haryana, 124001, India

    Versha Kajal, Sanjit Boora, Sapna Wadhwa, Kumari Soniya, Suman Yadav & Samander Kaushik

  2. Department of Genetics, Maharshi Dayanand University, Rohtak, India

    Sulochana Kaushik

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SB, VK, and SW have performed the conception or design of the study. SK, SK, KS, and SY in editing, acquisition, analysis, or interpretation of the data.

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Correspondence to Samander Kaushik.

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This article does not contain any studies involving animals performed by any of the authors. This article does not contain any studies involving human participants performed by any of the authors.

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Versha Kajal has no conflict of interest. Sanjit Boora has no conflict of interest. Sapna Wadhwa has no conflict of interest. Kumari Soniya has no conflict of interest. Suman Yadav has no conflict of interest. Sulochana Kaushik has no conflict of interest. Samander Kaushik has no conflict of interest.

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Kajal, V., Boora, S., Wadhwa, S. et al. In silico approaches for study the therapeutic potential of Cannabis sativa (Bhang) against HIV. ADV TRADIT MED (ADTM) 24, 285–303 (2024). https://doi.org/10.1007/s13596-023-00697-z

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