Download MendeleyTOM20-Driven E3 Ligase Recruitment Regulates Mitochondrial Dynamics Through PLD6
Xu, C., Zhao, S.(2025) Nat Chem Biol
9J78 | pdb_00009j78
Cryo-EM structure of CRL2-FEM1B (dimer 2)
- PDB DOI: https://doi.org/10.2210/pdb9J78/pdb
- EM Map EMD-61197: EMDB EMDataResource
- Classification: PROTEIN BINDING
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-08-18 Released: 2025-04-09
- Funding Organization(s): National Natural Science Foundation of China (NSFC)
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.88 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
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(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Elongin-B | A [auth H], D | 121 | Homo sapiens | Mutation(s): 0 Gene Names: ELOB, TCEB2 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q15370 (Homo sapiens) Explore Q15370 Go to UniProtKB: Q15370 | |||||
PHAROS: Q15370 GTEx: ENSG00000103363 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q15370 | ||||
Sequence AnnotationsExpand | |||||
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(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Cullin-2 | B, G [auth A] | 750 | Homo sapiens | Mutation(s): 0 Gene Names: CUL2 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q13617 (Homo sapiens) Explore Q13617 Go to UniProtKB: Q13617 | |||||
PHAROS: Q13617 GTEx: ENSG00000108094 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q13617 | ||||
Sequence AnnotationsExpand | |||||
| |||||
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(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Elongin-C | C, H [auth G] | 96 | Homo sapiens | Mutation(s): 0 Gene Names: ELOC, TCEB1 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q15369 (Homo sapiens) Explore Q15369 Go to UniProtKB: Q15369 | |||||
PHAROS: Q15369 GTEx: ENSG00000154582 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q15369 | ||||
Sequence AnnotationsExpand | |||||
| |||||
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(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Protein fem-1 homolog B | E [auth J], F | 627 | Homo sapiens | Mutation(s): 0 Gene Names: FEM1B, F1AA, KIAA0396 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9UK73 (Homo sapiens) Explore Q9UK73 Go to UniProtKB: Q9UK73 | |||||
PHAROS: Q9UK73 GTEx: ENSG00000169018 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9UK73 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 5 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| E3 ubiquitin-protein ligase RBX1, N-terminally processed | I [auth E], J [auth I] | 96 | Homo sapiens | Mutation(s): 0 Gene Names: RBX1, RNF75, ROC1 EC: 2.3.2.32 (UniProt), 2.3.2.27 (UniProt) |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P62877 (Homo sapiens) Explore P62877 Go to UniProtKB: P62877 | |||||
PHAROS: P62877 GTEx: ENSG00000100387 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P62877 | ||||
Sequence AnnotationsExpand | |||||
| |||||
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Entity ID: 6 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Poly-UNK | 9 | Homo sapiens | Mutation(s): 0 |  | |
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 7 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Poly-UNK | 8 | Homo sapiens | Mutation(s): 0 |  | |
Sequence AnnotationsExpand | |||||
| |||||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.88 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China (NSFC) | China | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-04-09
Type: Initial release
