KEGG DISEASE: Hepatitis B

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KEGG DISEASE: Hepatitis B

KEGG

DISEASE: Hepatitis B

Entry

H00412                      Disease

Name

Hepatitis B;
Hepatitis B virus (HBV) infection

Supergrp

Viral hepatitis [DS:H02162]
Fulminant hepatic failure [DS:H01712]

Description

Hepatitis B is an infectious disease caused by hepatitis B virus (HBV) belonging to the Hepadnaviridae family of dsDNA-RT viruses. Both acute and chronic hepatitis B can be caused by blood-borne HBV infections. The risk of developing chronic hepatitis B is directly related to the age of first infection, much higher for infants. Chronic hepatitis B may eventually lead to cirrhosis and hepatocellular carcinoma.

Category

Viral infectious disease

Brite

Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
  Viral hepatitis
   1E50  Acute viral hepatitis
    H00412  Hepatitis B
   1E51  Chronic viral hepatitis
    H00412  Hepatitis B
Genome-based classification of infectious diseases [BR:br08401]
Viral infections
  Infections caused by dsDNA-RT viruses
   H00412  Hepatitis B
Infectious diseases by law in Japan [br08406.html]
H00412

Disease
pathway

Hepatitis B

Network

nt06162 Hepatitis B virus (HBV)

Gene

IFNAR2 (susceptibility) [HSA:3455] [KO:K05131]
IFNGR1 (susceptibility) [HSA:3459] [KO:K05132]
IL10RB (susceptibility) [HSA:3588] [KO:K05135]

Pathogen

Hepatitis B virus (HBV) [GN:T40004]

Drug

Lamivudine [DR:D00353]
Tenofovir disoproxil fumarate [DR:D01982]
Adefovir dipivoxil [DR:D01655]
Entecavir [DR:D04008]
Telbivudine [DR:D06675]
Tenofovir alafenamide fumarate [DR:D10605]
Hepatitis B immune globulin [DR:D04431]
Interferon alfa-2b [DR:D02745]
Peginterferon alfa-2a [DR:D02747]

Other DBs

ICD-11:

MeSH:

MedlinePlus:

OMIM:

Reference

Authors

Nebbia G, Peppa D, Maini MK

Title

Hepatitis B infection: current concepts and future challenges.

Journal

QJM 105:109-13 (2012)
DOI:10.1093/qjmed/hcr270

Reference

Authors

Pramoolsinsup C

Title

Management of viral hepatitis B.

Journal

J Gastroenterol Hepatol 17 Suppl:S125-45 (2002)
DOI:10.1046/j.1440-1746.17.s1.3.x

Reference

Authors

Tan YJ

Title

Hepatitis B virus infection and the risk of hepatocellular carcinoma.

Journal

World J Gastroenterol 17:4853-7 (2011)
DOI:10.3748/wjg.v17.i44.4853

Reference

PMID:16757563 (IFNAR2, IL10RB)

Authors

Frodsham AJ, Zhang L, Dumpis U, Taib NA, Best S, Durham A, Hennig BJ, Hellier S, Knapp S, Wright M, Chiaramonte M, Bell JI, Graves M, Whittle HC, Thomas HC, Thursz MR, Hill AV

Title

Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.

Journal

Proc Natl Acad Sci U S A 103:9148-53 (2006)
DOI:10.1073/pnas.0602800103

Reference

PMID:19488747 (IFNGR1)

Authors

Zhou J, Chen DQ, Poon VK, Zeng Y, Ng F, Lu L, Huang JD, Yuen KY, Zheng BJ

Title

A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection.

Journal

Immunogenetics 61:423-30 (2009)
DOI:10.1007/s00251-009-0377-8

LinkDB

» Japanese version

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