KEGG DISEASE: Hepatitis C

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KEGG DISEASE: Hepatitis C

KEGG

DISEASE: Hepatitis C

Entry

H00413                      Disease

Name

Hepatitis C;
Hepatitis C virus (HCV) infection

Supergrp

Viral hepatitis [DS:H02162]
Fulminant hepatic failure [DS:H01712]

Description

Hepatitis C is a blood-borne infectious disease caused by Hepatitis C virus (HCV) belonging to the Flaviviridae family of +ssRNA viruses. HCV infection often becomes chronic and can lead to degenerative liver diseases including fibrosis and cirrhosis. Some of these may eventually lead to hepatocellular carcinoma.

Category

Viral infectious disease

Brite

Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
  Viral hepatitis
   1E50  Acute viral hepatitis
    H00413  Hepatitis C
   1E51  Chronic viral hepatitis
    H00413  Hepatitis C
Genome-based classification of infectious diseases [BR:br08401]
Viral infections
  Infections caused by +ssRNA viruses
   H00413  Hepatitis C
Infectious diseases by law in Japan [br08406.html]
H00413

Disease
pathway

Hepatitis C

Network

nt06163 Hepatitis C virus (HCV)

Gene

CCR5 (resistance) [HSA:1234] [KO:K04180]
IFNG (response to therapy) [HSA:3458] [KO:K04687]
IFNL3 (response to therapy) [HSA:282617] [KO:K22669]
PTPRC (susceptibility) [HSA:5788] [KO:K06478]

Pathogen

Hepatitis C virus (HCV) [GN:T40066]

Drug

Ribavirin [DR:D00423]
Simeprevir sodium [DR:D10469]
Sofosbuvir [DR:D10366]
Ledipasvir and sofosbuvir [DR:D10578]
Dasabuvir, ombitasvir, paritaprevir and ritonavir [DR:D10582]
Ombitasvir, paritaprevir and ritonavir [DR:D10745]
Elbasvir and grazoprevir [DR:D10778]
Sofosbuvir and velpatasvir [DR:D10827]
Sofosbuvir, velpatasvir and voxilaprevir [DR:D10900]
Glecaprevir and pibrentasvir [DR:D11014]
Interferon alfa-2b [DR:D02745]
Peginterferon alfa-2b [DR:D02748]
Peginterferon alfa-2a [DR:D02747]

Other DBs

ICD-11:

MeSH:

MedlinePlus:

OMIM:

Reference

Authors

Lingala S, Ghany MG

Title

Natural History of Hepatitis C.

Journal

Gastroenterol Clin North Am 44:717-34 (2015)
DOI:10.1016/j.gtc.2015.07.003

Reference

Authors

Lee MH, Yang HI, Yuan Y, L'Italien G, Chen CJ

Title

Epidemiology and natural history of hepatitis C virus infection.

Journal

World J Gastroenterol 20:9270-80 (2014)
DOI:10.3748/wjg.v20.i28.9270

Reference

PMID:15863470 (CCR5)

Authors

Goulding C, McManus R, Murphy A, MacDonald G, Barrett S, Crowe J, Hegarty J, McKiernan S, Kelleher D

Title

The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source.

Journal

Gut 54:1157-61 (2005)
DOI:10.1136/gut.2004.055699

Reference

PMID:17215375 (IFNG)

Authors

Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen HR, Thio CL, Thomas DL, Alter HJ, Sapp RK, Liang TJ

Title

A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection.

Journal

Proc Natl Acad Sci U S A 104:985-90 (2007)
DOI:10.1073/pnas.0609954104

Reference

PMID:19684573 (IFNL3)

Authors

Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, Sulkowski M, McHutchison JG, Goldstein DB

Title

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.

Journal

Nature 461:399-401 (2009)
DOI:10.1038/nature08309

Reference

PMID:16505159 (PTPRC)

Authors

Dawes R, Hennig B, Irving W, Petrova S, Boxall S, Ward V, Wallace D, Macallan DC, Thursz M, Hill A, Bodmer W, Beverley PC, Tchilian EZ

Title

Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection.

Journal

J Med Genet 43:678-84 (2006)
DOI:10.1136/jmg.2005.040485

LinkDB

» Japanese version

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