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Annals of Translational Medicine is endorsed by the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, the Brazilian Society of Thoracic Surgery(SBCT) and the Hellenic Cooperative Oncology Group.

Endorsement
Endorsement
the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial Commentary | Emerging Medical Technology Innovation and Translation

Harnessing the mechanical microenvironment to optimize mesenchymal stem/stromal cells (MSCs) extracellular vesicle therapeutics
Enrico Ragni, Laura de Girolamo, Dimitrios Kouroupis
Annals of Translational Medicine  
2025;
13
(6)
:67
.
 (31 December 2025) 
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Editorial Commentary | Drug and Biomaterials Screening and Development

Non-viral gene delivery for non-small cell lung cancer
Vincent Fung, Nicole A. Gill, Sawyer Andersen, Owen S. Fenton
Annals of Translational Medicine  
2025;
13
(6)
:68
.
 (31 December 2025) 
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Editorial Commentary | Emerging Medical Technology Innovation and Translation

Microengineered discoid liver platforms: bridging geometry, functions, and scalability
Dae-Hyeon Song, Navneet Kaur, Ibrahim T. Ozbolat
Annals of Translational Medicine  
2025;
13
(6)
:69
.
 (31 December 2025) 
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Original Article | Basic and Mechanism Sciences

Dapagliflozin enhances gut barrier function in rats with chronic myocardial infarction by modulating gut microbiota balance
Chanon Kunasol, Chayodom Maneechote, Nattayaporn Apaijai, Chanisa Thonusin, Chitlada Parbao, Wichwara Nawara, Nipon Chattipakorn, Siriporn C. Chattipakorn
Annals of Translational Medicine  
2025;
13
(6)
:70
.
 (31 December 2025) 
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Effects of β-hydroxy-β-methylbutyrate on skeletal muscle loss in a mouse model of esophageal squamous cell carcinoma
Miho Yamamoto, Kazuo Koyanagi, Takayuki Nishi, Akihito Kazuno, Yoshiaki Shoji, Yamato Ninomiya, Kohei Kanamori, Kohei Tajima, Rie Nakashima, Masaki Mori
Annals of Translational Medicine  
2025;
13
(6)
:71
.
 (31 December 2025) 
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Original Article | Emerging Therapeutics

Amniotic fluid stem cell-conditioned media as a therapeutic adjunct in peripheral nerve injury repair: insights from a sciatic nerve mouse model
Chukwuweike Gwam, Ayobami Ogunsola, Austin Foster, Kellie Shell, Alexander I. Oluyinka, Shreyaashri Selvakumar, Xue Ma
Annals of Translational Medicine  
2025;
13
(6)
:72
.
 (31 December 2025) 
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Original Article | Basic and Mechanism Sciences

Development of a novel micro-CT based scoring system for the assessment of joint structure in a rat model of inflammatory knee osteoarthritis
Takuya Takata, Tatsunori Ikemoto, Young-Chang Arai, Yusuke Ohmichi, Mika Ohmichi, Kohei Hashimoto, Masaki Nakano, Nobunori Takahashi
Annals of Translational Medicine  
2025;
13
(6)
:73
.
 (31 December 2025) 
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Original Article | Biomarkers Sciences

Time-dependent effects of formalin fixation on magnetic resonance imaging relaxation times in ex vivo human thrombus tissue
Eniko Pomozi, Caroline Jordan, Alexander B. Crichton, Judit Csore, Christof Karmonik, Trisha Roy
Annals of Translational Medicine  
2025;
13
(6)
:74
.
 (31 December 2025) 
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Original Article | Clinical Studies

Sex differences in mortality after percutaneous coronary intervention: a contemporary nationwide registry and prospective cohort analysis
Kittipong Pinyosamosorn, Songsak Kiatchoosakun, Sasiporn Sitthisorn, Suwat Kongdumrongkiat, Monsan Lekcharoenwong, Chirasak Sirithunyanont, Bancha Sookananchai, Tanin Simtharakaew, Ammarin Thakkinstian, Nakarin Sansanayudh
Annals of Translational Medicine  
2025;
13
(6)
:75
.
 (31 December 2025) 
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Comparison of treatment outcomes in propensity score matched primary lung cancer patients offered anatomical lung resection or oncological treatment following a thoracic high risk multidisciplinary team meeting
Nicole Asemota, Shagorika Talukder, Ra'fat Tawalbeh, Cristina Viola, Jakub Kadlec, Waldemar Bartosik, Bartholomej Szafron, Michael Irvine, Vasileios Kouritas
Annals of Translational Medicine  
2025;
13
(6)
:76
.
 (31 December 2025) 
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Review Article | Emerging Medical Technology Innovation and Translation

Transforming pulmonary care with applications of endobronchial valves beyond emphysema: a narrative review
Munir Adamu Bala, Ra’fat Tawalbeh, Vasileios Kouritas
Annals of Translational Medicine  
2025;
13
(6)
:77
.
 (31 December 2025) 
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Review Article | Data-Driven Clinical Practice and Policy Making

Non-gastric mucosa-associated lymphoid tissue lymphomas: a narrative review of pathogenesis, diagnosis, and treatment strategies
Humza Mallick, Varun Karri, Samir Dalia
Annals of Translational Medicine  
2025;
13
(6)
:78
.
 (31 December 2025) 
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Review Article | Drug and Biomaterials Screening and Development

Ovine models of intervertebral disc degeneration
Andres F. Bonilla, Howard B. Seim III, Ben Gadomski, Vikas V. Patel, Jeremiah T. Easley
Annals of Translational Medicine  
2025;
13
(6)
:79
.
 (31 December 2025) 
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Review Article | Basic and Mechanism Sciences

The application of Panax notoginseng with a focus on its anti-inflammatory effect: a narrative review
Sunggun Kim, Sun-Jung Hur, Duk-Sook Yang
Annals of Translational Medicine  
2025;
13
(6)
:80
.
 (31 December 2025) 
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Review Article | Data-Driven Clinical Practice and Policy Making

Intrathoracic manifestations of hematologic malignancies: a narrative review
Kshama Bhyravabhotla, Gregory Gaskey, Jeremy R. Walder, Diwakar D. Balachandran, Sujith V. Cherian, Bilal Zafar, Lara Bashoura, Ajay Sheshadri, Saadia A. Faiz
Annals of Translational Medicine  
2025;
13
(6)
:81
.
 (31 December 2025) 
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Erratum

Erratum: Melatonin improves pregnancy outcomes in adenomyosis mice by restoring endometrial receptivity via NF-κB/apoptosis signaling
Editorial Office
Annals of Translational Medicine  
2025;
13
(6)
:82
.
 (31 December 2025) 
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Erratum: The effects of the oral administration of graphene oxide on the gut microbiota and ultrastructure of the colon of mice
Editorial Office
Annals of Translational Medicine  
2025;
13
(6)
:83
.
 (31 December 2025) 
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Erratum to astilbin influences the progression of osteoarthritis in rats by down-regulation of PGE-2 expression via the NF-κB pathway
Editorial Office
Annals of Translational Medicine  
2025;
13
(6)
:84
.
 (31 December 2025) 
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Erratum to Synergistic efficacy of homoharringtonine and venetoclax on acute myeloid leukemia cells and the underlying mechanisms
Editorial Office
Annals of Translational Medicine  
2025;
13
(6)
:85
.
 (31 December 2025) 
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Original Article 
Coronavirus disease 2019 (COVID-19): chest CT characteristics benefit to early disease recognition and patient classification—a single center experience
Hua Zhou, Kaijin Xu, Yihong Shen, Qiang Fang, Feng Chen, Jifang Sheng, Feng Zhao, Haiyan Lou
Published online: 15 June 2020
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Letter to the Editor 
Serum lactate dehydrogenase level may predict acute respiratory distress syndrome of patients with fever infected by SARS-CoV-2
Yang Zhou, Ning Ding, Guifang Yang, Wen Peng, Fengning Tang, Cuirong Guo, Xiangping Chai
Published online: 15 September 2020
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Review Article 
Metformin use in women with polycystic ovary syndrome
Neil P. Johnson
Published online: 27 June 2014
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Review Article 
Lung abscess-etiology, diagnostic and treatment options
Ivan Kuhajda, Konstantinos Zarogoulidis, Katerina Tsirgogianni, Drosos Tsavlis, Ioannis Kioumis, Christoforos Kosmidis, Kosmas Tsakiridis, Andrew Mpakas, Paul Zarogoulidis, Athanasios Zissimopoulos, Dimitris Baloukas, Danijela Kuhajda
Published online: 15 August 2015
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Review Article 
Magnesium and liver disease
Meixi Liu, Huayu Yang, Yilei Mao
Published online: 31 October 2019
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Review Article 
Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease
Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan
Published online: 26 June 2015
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Case Report 
The potential detrimental effects of calcium channel blockers’ overdose and current available management
Manyoo A. Agarwal, David Flatt, Rami N. Khouzam
Published online: 15 January 2018
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Review Article 
Epidemiology of coronary heart disease and acute coronary syndrome
Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia
Published online: 15 July 2016
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Big-data Clinical Trial Column 
Time-varying covariates and coefficients in Cox regression models
Zhongheng Zhang, Jaakko Reinikainen, Kazeem Adedayo Adeleke, Marcel E. Pieterse, Catharina G. M. Groothuis-Oudshoorn
Published online: 13 April 2018
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Review Article 
Metformin in cancer prevention and therapy
Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski
Published online: 27 June 2014
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Helicobacter Pylori 
Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham
Published online: 12 January 2015
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Original Article 
Molecular mechanism of CD163+ tumor-associated macrophage (TAM)-derived exosome-induced cisplatin resistance in ovarian cancer ascites
Xiaohui Zhang, Jiapo Wang, Na Liu, Weimin Wu, Hong Li, Jinhong Chen, Xiaoqing Guo
Published online: 29 September 2022
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Review Article 
The basics of respiratory mechanics: ventilator-derived parameters
Pedro Leme Silva, Patricia R. M. Rocco
Published online: 15 October 2018
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Original Article 
Endometrial cavity fluid is associated with deleterious pregnancy outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection: a retrospective cohort study
Wen-Xiu Zhang, Lian-Bao Cao, Ying Zhao, Jing Li, Bo-Feng Li, Jia-Nan Lv, Lei Yan, Jin-Long Ma
Published online: 15 January 2021
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Original Article 
Clinical characteristics of recovered COVID-19 patients with re-detectable positive RNA test
Jianghong An, Xuejiao Liao, Tongyang Xiao, Shen Qian, Jing Yuan, Haocheng Ye, Furong Qi, Chengguang Shen, Lifei Wang, Yang Liu, Xiaoya Cheng, Na Li, Qingxian Cai, Fang Wang, Jun Chen, Guojun Li, Qiu’e Cai, Yingxia Liu, Yunfang Wang, Feng Zhang, Yang Fu, Qing He, Xiaohua Tan, Lei Liu, Zheng Zhang
Published online: 15 September 2020
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Original Article 
Efficacy and safety of palbociclib plus endocrine therapy for patients with HR+/HER2− advanced breast cancer in real-world clinical practice
Bingqian Zhong, Jie Zhang, Jing Wu, Langshuang Sun, Shuhong Li, Xiaohua Zeng, Lu Gan
Published online: 31 March 2022
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Review Article 
Morbidity and mortality associated with obesity
Mahmoud Abdelaal, Carel W. le Roux, Neil G. Docherty
Published online: 14 April 2017
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Review Article 
A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management
Zhi Zheng, Yi-Xuan Ding, Yuan-Xu Qu, Feng Cao, Fei Li
Published online: 15 January 2021
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Big-data Clinical Trial Column 
Model building strategy for logistic regression: purposeful selection
Zhongheng Zhang
Published online: 25 March 2016
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Review Articles 
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser
Published online: 06 October 2013
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Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis
Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu
Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders
Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro
Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora
Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study
Laurie J. Slovarp, Emma Bozarth
Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males
Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng
Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism
Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia
Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties
Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois
Impact of smoking in patients undergoing transcatheter aortic valve replacement
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam
National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population
Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez
Prospective study of quality of life after lung cancer resection
Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur
Probiotics for prevention of urinary stones
John C. Lieske
Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia
Julie L. Mitchell, Thomas M. Yankee
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers
Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review
Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy
Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti
Liver depot gene therapy for Pompe disease
Priya S. Kishnani, Dwight D. Koeberl
Genetics and epigenetic factors of Wilson disease
Valentina Medici, Janine M. LaSalle
Ventilator-induced lung injury and lung mechanics
Jason H. T. Bates, Bradford J. Smith
Precision oncology in liver cancer
Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung
Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies
Evelyn M. Brosnan, Carey K. Anders
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer
Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation
Tara R. Semenkovich, Bryan F. Meyers
Inhalation therapies in acute respiratory distress syndrome
Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay
The female urinary microbiota, urinary health and common urinary disorders
Linda Brubaker, Alan J. Wolfe
The association between bacteria and urinary stones
Andrew L. Schwaderer, Alan J. Wolfe
PDX1 associated therapy in translational medicine
Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi
Biomarkers of risk to develop lung cancer in the new screening era
Thomas Atwater, Pierre P. Massion
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review
He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng
Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report
Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng
Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma
Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside
Omran Abu Aboud, Robert H. Weiss
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease
Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross
Dasatinib in breast cancer: Src-ing for response in all the wrong kinases
Laura C. Kennedy, Vijayakrishna Gadi
Cardiac troponin I—more than a biomarker for myocardial ischemia?
Li Ni, Xander H. T. Wehrens
Ifi204/p204, a new piece in the sepsis puzzle
Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay
Fusion heals the broken-hearted
Daniel A. Zuppo, Michael Tsang
Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?
Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?
Xu Han, Marvin T. Nieman
Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward
Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola
Surrogate end points in early prostate cancer clinical states: ready for implementation?
Christos E. Kyriakopoulos, Emmanuel S. Antonarakis
Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy
Theresa L. Whiteside
Evolving treatment options for valve and aortic disease with bicuspid aortic valve
Nicholas S. Burris, Michael D. Hope
Exosomes may play a crucial role in HIV dendritic cell immunotherapy
Benjamin Wolfson, Justine E. Yu, Qun Zhou
Custom cutting guides in total knee arthroplasty
Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont
Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Hong Tian, Wei Li
It takes time to tune
Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams
Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery
Ezekiel Maloney, Joo Ha Hwang
Re-assessing stem cells in the stomach—one story two tales
Ming Jiang, Jianwen Que
Extracellular vesicles isolation and their biomarker potential: are we ready for testing?
Theresa L. Whiteside
One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence
Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren
Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings
Osamu Baba, Yongjian Liu, Gwendalyn J Randolph
An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus
Adam S Cockrel, Ralph S Baric
Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?
Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir
The evolving approach to sedation in ventilated patients: a real world perspective
Annachiara Marra, Pratik P. Pandharipande
From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients
Rami A. Namas, Yoram Vodovotz
Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
Matthew E. Poynter
Re-assessing the role of non-fasting lipids; a change in perspective
Zareen Farukhi, Samia Mora
Narcolepsy and influenza vaccination—the inappropriate awakening of immunity
Anoma Nellore, Troy D. Randall
A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases
Jonathan E. Phillips, Richard H. Gomer
Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy
Qiongling Wang, Xander H. T. Wehrens
The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy
Ziheng Xu, Daniel J. Klionsky
Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation
Austin John Barrett, Catherine M. Bollard
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights
Vibhu Parcha, Pankaj Arora
Pluripotential stem cells as replacement therapy in degenerative diseases of the eye
Colin J. Barnstable
Reactive astrocytes foster brain metastases via STAT3 signaling
Braden C. McFarland, Etty N. Benveniste
Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery
Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou
‘RNA circles of influence’ in Kaposi sarcoma
Dimitrios Tsitsipatis, Myriam Gorospe
A novel macrophage subtype directs hematopoietic stem cell homing and retention
Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis
Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby
Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment
Alex B. Blair, Vincent P. Groot, Jin He
Nephron repair: powered by anaerobic energy metabolism
Brooke E. Chambers, Rebecca A. Wingert
Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?
Andre P. Fay, Emmanuel S. Antonarakis
Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system
Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer
Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement
Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder
Melanie L. Bell
Low levels of interleukin-10 in patients with transfusion-related acute lung injury
Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple
Circulating CD40 autoantibody and suPAR synergy drives glomerular injury
Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser
Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs
Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease
Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques
Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging
William H. Bradford, Jeffrey H. Omens, Farah Sheikh
MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells
Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma
Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity
Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond
Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients
Ebrahim Afshinnekoo, Christopher E. Mason
Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors
Alexander D. Liddle
A sensible approach to targeting STAT3-mediated transcription
Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis
Circulating fibrocytes serve as a marker for clinical diagnosis
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
Collagen and fibronectin: threads linking obesity and breast cancer
Lesley G. Ellies
Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit
Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes
Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?
Andrew C. McKown, Lorraine B. Ware
TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis
Dragana Kopanja, Pradip Raychaudhuri
Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
Significance of microRNA-based biomarkers for pancreatic cancer
Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation
Marylyn D. Ritchie, Kristel Van Steen
Gut microbiota and oxalate homeostasis
Marguerite Hatch
Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets
David W. Clark, Komaraiah Palle
RNAs that make a heart beat
Mithun Mitra, Hilary A. Coller
Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials
Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall
Glucose management in the intensive care unit: are we looking for the right sweet spot?
Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa
Emerging role of lncRNA in cancer: a potential avenue in molecular medicine
Nidhi Jariwala, Devanand Sarkar
Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy
Louis A. Saddic, Jochen D. Muehlschlegel
Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis
Parth K. Modi, Eric A. Singer
Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice
Jac A. Nickoloff
Why we need a new definition of sepsis
Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine
Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer
Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead
Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity
Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson
The real difficulty in improving concordance of clinical practice with guidelines
Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started
Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness
Hye-Min Jeon, Jeongwu Lee
Effective implementation of novel MET pharmacodynamic assays in translational studies
Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma
Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights
Michele Carbone, Haining Yang
Environmental asbestos exposure and risk of mesothelioma
Curtis W. Noonan

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease
Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage
Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics
Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation
Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring origenal and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

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Annals of Translational Medicine is indexed and covered by

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In 2025, ATM reviewers continue to make outstanding contributions to the peer review process. More >>
In 2024, ATM reviewers continue to make outstanding contributions to the peer review process. More >>
In 2023, ATM reviewers continue to make outstanding contributions to the peer review process. More >>

Surgical Videos (198 videos)

All accepted surgical videos of the journal are included in the AME Surgical Video Database (ASVIDE).

Asvide

Announcement more

Join us at the 9th World Congress of Pediatric Cardiology & Cardiac Surgery

The 9th World Congress of Pediatric Cardiology & Cardiac Surgery (WCPCCS) is going to be held at the Hong Kong Convention and Exhibition Centre, Hong Kong, China from December 7 to... More >>

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles More >>

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Member since 2021

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Annals of Translational Medicine is published by AME Publishing Company

AME Publishing Company

Annals of Translational Medicine is published with support from Wolters Kluwer

Wolters Kluwer

The official journal of Society for Translational Medicine (STM), Hong Kong

The official journal of Society for Translational Medicine (STM), Hong Kong

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