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TCR 2024 Annual Report

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Original Article

Development and validation of a prediction model based on two-dimensional dose distribution maps fused with computed tomography images for noninvasive prediction of radiochemotherapy resistance in non-small cell lung cancer
Min Zhang, Ya Li, Yong Hu, Bo Du, Youlong Mo, Tianchu He, Yang Yang, Benlan Li, Ji Xia, Zhongjun Huang, Fangyang Lu, Bing Lu, Jie Peng
Targeting PAR-2-driven inflammatory pathways in colorectal cancer: mechanistic insights from atorvastatin and rosuvastatin treatment in cell line models
Rajashree Patnaik, Riah Lee Varghese, Sara Khan, Bintul Huda, Farida Bhurka, Layla Amiri, Yajnavalka Banerjee
Oncologic and obstetric outcomes of a novel nerve-sparing radical trachelectomy while preserving the uterine branches of the pelvic nerves
Kentaro Nakayama, Sultana Razia, Tomoka Ishibashi, Hitomi Yamashita, Kosuke Kanno, Masako Ishikawa, Seiya Sato, Haruo Takeshita, Satoru Kyo
Risk factors, prognostic factors and nomograms for distant metastasis in colorectal neuroendocrine neoplasms: a SEER-based study
Yuqin Bai, Na Lei, Pan Zhang, Qian Yang, Fei Feng, Yue Zhao
Prediction of visceral pleural invasion of clinical stage IA lung adenocarcinoma based on computed tomography features
Deng Lyu, Yun Wang, Wenting Tu, Su Hu, Yanqing Ma, Xiuxiu Zhou, Yi Xiao, Rongbo Dong, Li Fan, Shiyuan Liu
Incidence, clinical features, and survival outcomes of primary malignant conjunctival tumor: a US population-based retrospective cohort analysis based on the SEER database (1975–2018)
Lin-Feng He, Shi-Yi Tang, Yu-Jiao Wang, Yun Zhang, Sheng-Mei Huang, Xiao-Jing Huang
Small peritoneal macrophages are accelerators of peritoneal metastasis of colorectal cancer
Wanli Yang, Feng Jiang, Lixia Xu, Nan Pang, Chao Yang, Ruihua Yu, Haiqun Chen
Scoparone suppresses proliferation and cell cycle of hepatocellular carcinoma cells via inhibiting AKT/GSK-3β/cyclin D1 signaling pathway
Mei Hong, Hao Zhu, Weikang Liu, Pengyu Zhang, Song Yu, Quangen Gao, Genhai Shen, Bin Li, Gang Wang
Development and validation of nomograms for predicting the prognosis of colorectal cancer patients
Yingqi An, Jianping Gong, Aitang Xiao
Triage of women with positive HPV: comparing DNA ploidy analysis with HPV 16/18 genotyping and cervical cytology
Wei Song, Lan Zhu, Min Zheng, Hua Liu
Comprehensive analysis of molecular characteristics between primary and breast-derived metastatic ovarian cancer
Junqi Long, Bo Liu, Jinmeng Li, Xinchan Ji, Nian Zhu, Xujie Zhuang, Huina Wang, Lujia Li, Yuhaoran Chen, Xiaohui Li, Shuangtao Zhao
Comparative survival analysis of stage T1-T2N0M0 lung squamous cell carcinoma and adenocarcinoma using SEER data, and nomogram analysis for early-stage lung squamous cell carcinoma
Chang Liu, Cheng Fang, Dan Shen
Individualized estimation of conditional survival for patients with spinal chordoma
Xiaoyu Ren, Fei Cong, Gao Chao, Cheng Yang, Yunshan Guo, Jinzhu Fan
Revisiting lymph node guidelines: limited lymph node examination might be sufficient for elderly gastric cancer patients
Xiaojie Zhang, Tao Fu, Guochao Zhang, Haibin Liu, Lin Zhang, Zongze Li, Shengnan Zhou, Lei Zhou
Identification of novel neutrophil-extracellular-traps-related genes as biomarkers for breast cancer prognosis and immunotherapy
Zhen Huang, Chongde Mo, Lihui Li, Qiyan Hou, Yinhua Pan, Guiyue Zhu, Fangyu Qiu, Quanqing Zou, Jianrong Yang
Predicting bone marrow suppression from urinal 8-hydroxy-2'-deoxyguanosine level during the treatment with radium-223 in patients with cancer bone metastasis
Satoru Monzen, Yoshihiko Kasai, Ryota Kinbara, Katsuhiko Suto, Yuki Morino, Kenji Terada, Andrzej Wojcik, Yasushi Mariya
Association between diffusion-weighted imaging and tumor matrix in liver cancer: a cross-sectional study
Hans-Jonas Meyer, Johann Potratz, Dörthe Jechorek, Kai Ina Schramm, Jan Borggrefe, Alexey Surov
Molecular subtype and prognostic model of laryngeal squamous cell carcinoma based on neutrophil extracellular trap-related genes
Guiqin Wu, Riqun Jin, Jiahua Liao, Jianhua Zhang, Xuemei Liu
KRT14 knockdown reduces cisplatin resistance by lowering LRP11 expression levels in cisplatin-resistant ovarian cancer cell lines
Zequn Liu, Tingsong Weng, Mi Cheng, Tingying Lei, Du Xiao, Qiong Deng, Tianmei Wu
Integrated machine learning constructed a circadian-rhythm-related model to assess clinical outcomes and therapeutic advantages in hepatocellular carcinoma
Ziyuan Xu, Wei Huang, Xi Zou, Shenlin Liu
Estrogen receptor β inhibits breast cancer migration and promotes its apoptosis through NF-κB/IL-8 signaling
Yanke Sui, Zuge Liu, Yao Yao, Shuting Zhang, Yuxiang Wang, Yuanyuan Wang, Bin Kong
Radiomics-clinical nomogram for preoperative tumor-node-metastasis staging prediction in breast cancer patients using dynamic enhanced magnetic resonance imaging
Zhe Yang, Shouen Wang, Wei Yin, Ying Wang, Fanghua Liu, Jianshu Xu, Long Han, Chenglong Liu
Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study
Jinsong Lei, Longjun Yang, Gongming Wang, Qianwen Liu, Guangran Guo
Analysis and assessment of ferroptosis-related gene signatures and prognostic risk models in skin cutaneous melanoma
Jianchao Ma, Yang Cai, Youqi Lu, Xu Fang
Feasibility and patient reported tolerance of cryotherapy with Cooral mouth cooling device in patients undergoing radiation therapy (CooRay): a pilot study
Andrei Bunea, Tiberiu Damian, Hatice Bunea, Tobias Finazzi, Tristan Bauer, Jens Lustenberger, Shirin Davarpanah Jazi, Alexandros Papachristofilou
Prediction of the prognosis of intrahepatic cholangiocarcinoma patients after hepatectomy via propensity score matching: a competitive risk model analysis
Shu-Sen Jiang, Zhi-Yu Wang, Li-Jun Tan, Li-Xia Zhou, Xue-Yao Wang, Xin-Meng Han, Shun-Gang Li, Ji-Meng Luo, Hong-Bing Yao
Enhanced prognostic prediction of cancer-specific mortality in elderly bladder cancer patients post-radical cystectomy: an XGBoost model study
Gaowei Li, Kang Xia
A novel mesenchymal epithelial transition (MET) inhibitor, CB538, relieves acquired resistance in EGFR-mutated MET-amplified non-small cell lung cancer
Ji Yeon Song, Hyunsook An, Soojeong Kim
Survival analysis of gastric malignancy patients: identifying key prognostic factors
Deng Han, Zhiyu Zhang, Jinyan Deng, Hongbo Du
Induction of ferroptosis in oxaliplatin-resistant colorectal cancer cells by extract from Actinidia chinensis Planch radix
Jun Lu, Yuhuan Wang, Wei Cui, Chenyang Ma
Impact of Shenling Baizhu Powder on lipid profiles and body mass index in breast cancer patients under adjuvant chemotherapy: a retrospective study
Jiaqing Song, Ying Jin, Qinghong Yu, Hongting Wu, Hailong Li, Geok Hoon Lim, Marcelo Antonini, Xiufei Gao
The identification and prediction of lung adenocarcinoma prognosis using a novel gene signature associated with DNA replication
Xiujuan Wu, Qiang Xu, Paerhati Aiyiti, Defeng Meng, Jingang Zhang, Fabrizio Citarella, Petros Christopoulos, Tong Liu, Wei Duan
Causal relationship between gut microbiota and malignant lymphoma: a two-way two-sample mendelian randomization study
Shixue Laoguo, Jing Tang, Xiaoyu Xu, Xianye Huang, Yanfeng Jiang, Ning Mo, Shanlin Duan, Weizhen Wu, Hening Li, Justin Taylor, Jie Ma
Biological and clinical significance of circulating mucosal-associated invariant T cells in lung cancer
Jingjing Liu, Haoyu Wang, Xiaotao Wang, Jacek Jassem, Jiming Si, Yuanhua Liu, Jianjun Jin
Development of coenzyme Q10-related molecular subtypes and a prognostic signature for predicting breast cancer prognosis and response to immunotherapy
Zhou Fang, Shi-Chong Liao, Yue-Yue Guo, Juan-Juan Li, Zhong Wang, Yi-Min Zhang, Feng Yao
Research on the error pattern recognition of dosimetric quality assurance by Bayesian optimization
Yewei Wang, Xueying Pang, Helong Wang, Yanling Bai
Retrospective study on the prognostic prediction of inflammatory markers and the C-reactive protein/albumin ratio in first-line immunotherapy for advanced HER2 negative gastric cancer patients
Yan Sun, Fei Yan, Xinnian Yu, Zijian Sun, Guoren Zhou
A gene signature associated with cellular senescence serves as an important prognostic indicator in hepatocellular carcinoma
Yongfeng Yan, Kai Chen, Qian Sun
Diagnostic test of conventional ultrasonography combined with contrast-enhanced ultrasound in the subcategorization of suspicious Breast Imaging-Reporting and Data System (BI-RADS) 4 breast lesions
Yindi Zhu, Dian Zhang, Xiao-Na Wang, Yue-Nan Chen, Mei-Fang Pan, Susanna Guerrini, Eugene Ong, Xin-Xian Gu, Li Jiang
Arsenic enhances cervical cancer cell radiosensitivity by suppressing the DNA damage repair pathway
Xingxing Gao, Genyun Liu, Zimu Zhao, Yi Tang, Hui Hui, Chaoqun Wang, Danhua Li, Yu Ma, Zhuo Sun, Yun Zhou
Investigation of mitochondrial DNA methylation-related prognostic biomarkers in hepatocellular carcinoma using The Cancer Genome Atlas (TCGA) database
Shanfan Shi, Wen Liang, Yunxue Qie, Runtong Wu, Yejin Zhu
Construction of a postoperative liver metastasis prediction model for colorectal cancer based on spectral CT imaging, CEA, and CA19-9
Qingyong Yang, Chenguang Bai, Yongzi Xu, Yan Sun, Diamantis I. Tsilimigras, Yousheng Lu
Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018
Review Articles 
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Published online: 01 August 2012
Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origen
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.